Welcome to the first ever International PNH Interest Group (IPIG) International Conference (in-person event only) to convene Thursday through Friday, 18-19 May 2023, at The Crown Hotel in Harrogate, UK. The IPIG Board of Directors and Conference Program Committee are finalizing a compelling agenda and look forward to spirited discussions and meaningful dialogue at this conference.

Topics included in the two-day conference are as follows:

• Pathophysiology of PNH, focusing on biologic aspects of the GPI-defect in PNH and on the mechanism expansion of PNH hematopoiesis, as well as on complement biology
   

• Current thoughts on the treatment of PNH, including anti-complement therapies for hemolytic/thrombotic PNH, immunosuppressive treatment for bone marrow failure, as well as bone marrow transplantation
   

• Hot Topics in PNH (defining response and endpoints, breakthrough hemolysis: terminal vs proximal inhibitors, proximal inhibitors: monotherapy vs combination treatment)
   

• A special session entirely dedicated to recent data coming from clinical trial investigating complement inhibitors in PNH.
   

• World-wide impact of PNH, focusing on geographic area-specific unmet clinical needs
   

• ​Ongoing collaborative projects of IPIG: the IPIG PNH International Registry

We hope to see you in May in Harrogate!

Sincerely,
Antonio Risitano, MD, PhD
Chair